A survey published on PloS Medicine considers the effects of "the happiness pill clinically nonexistent". And in Great Britain this survey resulted in an outbreak of controversy. Prozac, the antidepressant Seroxat and in general antidepressants do not produce clinically significant benefits. It had the effect of an earthquake relationship. Irving Kirsch, director of the psychology department of Hull University, which - published in the online journal PloS Medicine - assess the outcomes of total 47 studies (known and unpublished) of British and American experts on the real effects of "happiness pill", Prozac. Printed immediately on the front pages of major British newspapers, The Guardian and The Independent Times immediately attacked by the pharmaceutical companies concerned. The study argues that this type of medicines - given annually by more than 40 million people around the world -- found minimal improvements compared to the simple placebo, amounting to just two points on the Hamilton depression scale (comprising 51 points total). Findings for fluoxetine (Prozac), venlafaxine (Efexor), paroxetine (Seroxat) and similar molecules have been put on the market, but which do not reach the three points needed by the British National Institute for Clinical Excellence (Nice) to recognize their significant clinical differences .