The "Reactable", is a multi-user electronic music instrument with a table-like user interface. It can be played by more than one people, who move objects on a luminous table surface. It's freakin' awesome!

The largest nuclear weapon ever constructed or detonated was the Russian Tsar Bomba . It was detonated at 4000 m altitude the 30th of October 1961 at Mityushikha Bay test range, on the Novaya Zemlya Island. It had a yield of 50 Megatons. Awesome power!!!

Some people are actively looking for trouble. This young teen, thought he would impress his mates by knocking the sh!t out of a concrete fence/wall (they're segmented, and we have them in my country too). Guess what? The fence fought back! Lol. Moron!

This fantastic new active car suspension has amazed everyone. Not only that you don't feel speed bumps and hard corners, but you can do some "tricks" if you want to. Have a look at the demonstration video and see for yourself!

A sexy photo shoot by Caprice lingerie, from which some photos made the front cover of Maxim magazine. I'm sure you'll enjoy this hot model in lingerie and bikini. Very attractive. Enjoy this sexy video photo shoot!

The molecule slows the proliferation of tumor cells while giving the time needed to repair the damage to their DNA. The discovery, made by Italian researchers IEA, is published in Nature. The secret of immortality of cancer stem cells - those that feed it and cause relapses because they're immune to chemotherapy - was unveiled. Their strength is the p21 protein that slows the proliferation, giving them the time needed to repair damage to DNA. In practice, it is as if these cells were able to rejuvenate indefinitely: no age, and thus do not die. By blocking the production of p21, however, you can make them vulnerable and hit the tumor at the root. The research was conducted in the laboratories of the European Institute of Oncology (IFOM-IEO) in collaboration with the universities of Milan and Perugia, and was published this week in Nature. The cells age and die because they accumulate damage and mistakes borne of DNA during cell divisions. To understand why this does not happen in a cancerous stem cell, the researchers observed what happens to a staminale "normal" when you alter one of the genes (oncogenes) that cause cancer (in this case, the acute myeloid leukemia). The study revealed that oncogenes stimulate the activity of another gene, called p21, and thus the production of the corresponding protein, whose effect is to slow the proliferation. In essence, these cells have much more time to repair other damaged DNA, and remain young and active, immune to chemotherapy drugs because they recognize and affect only the cells in rapid proliferation.

An enzyme that can rewind the DNA at points where the two propellers should remain separate, even fatal, causing disturbances. The cause of some serious diseases, such as the rare immune-dysplasia of bone Schimke is a protein able to settle the two propellers of DNA at points in which they should remain separate and thus induce the expression of genes that would otherwise be idle. Under normal circumstances the DNA presents a series of "bubbles", namely the segments in which there is space between them and raggomitolate. The unusual alignment of the two parallel strips, led by newly discovered protein, called Harp (HEPA-related protein), reactivates the expression of genes in these traits, which may in this way to start even occurrence of very serious diseases. The enzyme is and was discovered by James Kadonaga and Timur Yusufzai, two biologists at the University of San Diego (California) authors whose research results were published in Science. Just as a zip, the enzyme flows on the tape of DNA tangles the lines and welding to the two separate entities, thereby according the traits of nucleic acid that ordinarily are designed to remain inactive. Exactly the opposite of what another enzyme, the "elicasi", which has the role to unwind the DNA during replication of the molecule, being essential for life. The protein discovery is only the first of an entire class of enzymes candidates to be the basis of occurrence of disorders characterized by cardiac or kidney malfunction, with even fatal effects on children.

Npas4: This protein regulates the formation of inhibitory synapses between neurons. The inhibitory activity of neurons is regulated by a particular switch. This is a protein involved in the formation and maintenance of synapses in regulating selectively switching the electrical signal between nerve cells. Its name is Npas4 and was discovered by researchers from the Children's Hospital in Boston this week to publish their study in Nature. In particular, the protein in question is a transcription factor, that is a molecule that can activate or deactivate specific genes. Those which would be linked to Npas4 are more than 270. When the protein is produced in large quantities, we are seeing an increase in the number of inhibitory synapses on the surface of nerve cells. But what induces the production of high levels of Npas4? According to the researchers this is a reaction to excitatory synaptic. "It is as if the same excitement triggers a program to rebalance the brain with inhibition," says Michael Greenberg, coordinator of the study, which continues: "The mice in which the protein is suppressed, in fact, have neurological problems: are anxious, hyperactive and more subject to seizures. " The discovery could help researchers in studying these disorders. Inhibition, in fact, plays an important role in brain development.

The ventral striatum, a part of the brain already known to be associated with rewards and unexpected stimuli, is the center of our desire for adventure. The research in Neuron. A group of researchers from the Wellcome Trust Centre for Neuroimaging at the University College of London has identified the area of the brain directly linked to our desire for adventure. Or, more precisely, our propensity to live new experiences and to experience what we do not know. For the study, published in Neuron, researchers have developed a test: the participants were presented a series of images associated with different sums of money put into a premium, and were asked to guess which of the sums was higher. Although the volunteers easily could identify the image associated with richer rewards, when it was introduced a new figure, all of them tended to choose the latter rather than those already known with secure profits. Through magnetic resonance imaging, neuroscientists have noticed that the area of the ventral Striatum (an area of the brain already known to be associated to receive a reward and unexpected stimuli) was particularly active when participants opted for the novelty.

Three hours of jogging or 13 of walking per week: according to a U.S. study moderate exercise reduces the risk of breast cancer Being fit, as we know, is not only an aesthetic issue. And now it seems that it is also useful for the prevention of breast cancer. A study of about 65,000 women by researchers at Washington University School of Medicine in St.. Louis and from Harvard University in Boston, just published in Journal of the National Cancer Institute, points out that women practicing sports have a 23 per cent lower risk of developing cancer before the menopause. In particular, it may be important to regularly exercise between the ages of 12 and 22 years. "We have prevention strategies for breast cancer pre-menopausal, but our research shows that physical activity during adolescence and youth, between 12 and 35 years, may be important in the long term reduction of the risk of cancer", said Graham Colditz, professor of Prevention and Control and co-director at the Siteman Cancer Center, Washington University School of Medicine and Barnes-Jewish Hospital. "This is just one more reason to encourage young women to exercise regularly."

At the Ifom-Ieo Campus, a study began on the operation of a molecule which opens new avenues of research for less toxic treatments in chemotherapie. The study in Cell magazine. Developing new chemotherapies able to kill cancer cells without harming healthy ones: This is the goal that's still far away but we can see the light. Thanks to an international study to which has substantially contributed a team of Campus Ifom-Ieo (Foundation Institute of Molecular Oncology - European Institute of Oncology) in Milan, in fact, it was possible to identify a molecule - called Ndc80 - which could be the ideal target of new chemotherapeutic drugs, because it's active only when the cell reproduces (mitosis). The research, led by Andrea Musacchio in collaboration with Peter De Wulf, was published in the journal Cell. One of the problems with current chemotherapies is that, in addition to attacking the cancer cells, in part it also kills healthy cells. This is because the drugs (for example, taxolo) affect proteins that, although mostly engaged in the process of cell proliferation (typical of tumor masses), they are also involved in other processes with other cells that are not sick. A molecule found only in reproducing cells would be the ideal target.