A funny video from "The Price is Right" Tv show, where a stoned guy makes some absurd bid of seventeen hundred dollars! Watch and be amazed!

Here's a funny video clip of spiders on drugs, and how their webs are affected when they are on different drugs like coffeeine, alcohol, crack cocaine and LSD. Enjoy.

What can I say? I think that the footage speaks for itself. Steve-O, the popular character from Jackass, must've been on drugs or something. I just can't understand what was he thinking?!

Maybe some could learn from the weekly chases in the US, But apparently this guy doesn't watch because he's too busy getting stoned. And look where it got him...tasered by the cops!

After a raid on a drug dealer in Mexico, the cops were stunned to find 207 million dollars in cash piled in one of the house's bedrooms. Wow! Now that's an amazing find!

The particles of cobalt-chromium can cause DNA damage even if they do not come physically into contact with the cells. The nano-particles manage to damage the DNA of cells protected by a barrier made up of cellular membranes, without physically entering into contact with the cell, but rather through a multitude of chemical signals. This was found in a study coordinated at the Bristol Implant Research Center, proving that it brings out a new risk associated with nanotechnology, but also the opportunity to exploit this behavior in an innovative way. Nano-particles are now widely used. In surgery, for example, are an integral part of prostheses and implants. The research conducted so far on the risks of nanoparticles, however, relates mainly to the effects of direct exposure, while very little is known about what can cause the indirect exposure. In the new study, researchers have wondered if a barrier device was able to protect cells from the effects of nano-particles consisting of chromium and cobalt in the tissues of the clothes and orthopedic implants. The researchers interposed a barrier between nanoparticles formed out of multilayer chromium-cobalt (in quantities thousands of times greater than those with whom we come in contact normally) and a culture of human fibroblasts (connective tissue cells). Although nano-particles have not managed to cross the membrane, the fibroblasts had DNA mutations which were ten times more than the control fibroblasts. According to scholars, the effect is due to chemical signals between the cell membrane and fibroblasts. If the lines of communication between them are broken, the rate of DNA damage returned to normal.

This study researched killing cancer cells with nano-magnets, with the same principle as a microwave oven. The study of nano-particles applied to biomedicine continues to give interesting results, as research is still in its infancy. Through their work, the chemists from the university of Cagliari are now investigating some of the possibilities opened by this field. One is to use magnetic particles to convey the drugs only to the diseased cells, the other is to drive up the tumor and then force them to oscillate under the control of a variable magnetic field, thereby heating the target cells, just like a microwave oven does with the water molecules contained in food. This second mechanism exploits hyperthermia. It appears that cancer cells can be destroyed by beeing brought to a temperature of 42.5 degrees Celsius for about half an hour. In order arrive at the place desired, the particles must be incorporated into liposomes, hollow microspheres formed by lipid bilayers (for which reason they are called "magneto-liposomes"), which are able to overcome the barrier of cells. They must have a diameter of about 20 nanometers. Larger could indeed block blood vessels, while smaller particles may be "eaten" by macrophage cells which are in charge with the elimination of foreign bodies. Currently, the research team is working on the synthesis of particles and study of their structural and magnetic properties. Currently these are being built in oxide of iron or iron cobalt. The latter are more manoeuvrable, because their magnetic properties depend strongly on the direction along which the field is applied to (property known as magnetic anisotropy).

The molecule slows the proliferation of tumor cells while giving the time needed to repair the damage to their DNA. The discovery, made by Italian researchers IEA, is published in Nature. The secret of immortality of cancer stem cells - those that feed it and cause relapses because they're immune to chemotherapy - was unveiled. Their strength is the p21 protein that slows the proliferation, giving them the time needed to repair damage to DNA. In practice, it is as if these cells were able to rejuvenate indefinitely: no age, and thus do not die. By blocking the production of p21, however, you can make them vulnerable and hit the tumor at the root. The research was conducted in the laboratories of the European Institute of Oncology (IFOM-IEO) in collaboration with the universities of Milan and Perugia, and was published this week in Nature. The cells age and die because they accumulate damage and mistakes borne of DNA during cell divisions. To understand why this does not happen in a cancerous stem cell, the researchers observed what happens to a staminale "normal" when you alter one of the genes (oncogenes) that cause cancer (in this case, the acute myeloid leukemia). The study revealed that oncogenes stimulate the activity of another gene, called p21, and thus the production of the corresponding protein, whose effect is to slow the proliferation. In essence, these cells have much more time to repair other damaged DNA, and remain young and active, immune to chemotherapy drugs because they recognize and affect only the cells in rapid proliferation.

By comparing DNA of healthy and cancerous tissue of a single person, there were discovered eight new mutations linked to the disease. The study in Nature The complete genome of a person suffering from cancer was decoded for the first time. The comparison between the DNA of normal and cancerous tissue of a woman suffering from acute myeloid leukemia (AML) has identified ten mutations in the genome of cancer cells, including eight so far unknown, which would be linked to the disease. Researchers of the Washington University School of Medicine (USA), coordinated by Richard K. Wilson, presented their findings in Nature. Scientists have taken a sample of tissue from normal skin and a tumor tissue from bone marrow to a patient suffering from AML - cancer that affects the bone marrow cells that produce red blood cells. Subsequently they have decoded the DNA of the two tissues, comparing all three billion bases of which the genomes were composed, to go back to differences in disease characteristics of the individual. There were ten mutations identified, two already known, eight first ever linked to the disease. Of those, three were found in genes that normally can block the growth of tumors (for example in Ptprt, the tyrosine phosphatase gene, often altered in colon cancer). Four changes instead involved genes regulate the molecular pathways that promote tumor development - particularly in a family of genes, usually expressed in embryonic stem cells, which could stimulate cell renewal. A final disturbing deterioration instead of transporting drugs into the cell. According to scientists, these mutations have occurred one after another, each adding something new to the tumor.

To isolate individual cells of the immune system and study the interaction in order to improve the treatment of cancer. At this will serve the new biosensor prototype developed under the project Cochise (Cell-On-CHIp bioSEnsor), supported by the European Union and coordinated by Roberto Guerrieri, professor of Electronics at the Faculty of Engineering, University of Bologna . The biological approach used to treat cancer patients consisting of interferon, interleukin-2 or other factors stimulating the growth of different cell types and able to reinforce the natural defenses of the body. But these substances are not always well tolerated. An alternative approach is to identify the immune cells able to fight cancer, cultivate them in vitro and then re-introduce them in the body. But here the problem lies in identifying and in isolating the small number of cells that are selectively able to fight cancer. The objective of the project Cochise (which is intended to last three years), is to develop a new class of biosensors capable of isolating cells (not more than 1 in 10 thousand) that are actually effective in fighting cancer cells . As the first objective was developed a prototype, used to demonstrate the possibility of controlling the flow of two individual cells and putting them in a display where you can study the interaction.

A study explains how a yeast cell becomes cancerous: the fault is a chromosomal translocation An altering of the genome that causes cancer was finally detected and reproduced in the laboratory. The discovery, crucial for understanding the genesis and development of malignancies, is due to the geneticist Charles V. Bruschi, head of the Laboratory of Molecular Genetics of yeast, International Centre for Genetic Engineering and Biotechnology in Trieste (Icgeb) and coordinator of the Society of Italian scientific yeast (Zymi). Together with his group, Bruschi has uncovered, that the so-called chromosomal translocation is at fault. The yeast cells, whose DNA was sequenced completely in 1996, are a good model because they possess many similarities with mammalian cells and are easily manipulated by genetic engineering. Thanks to technical Bit (Bridge-Induced Translocation), designed by Bruschi and Valentina Tosato in 2005, it was possible to artificially induce the translocation and demonstrate the crucial role of this phenomenon in the formation of cancer. "Although it has long been a correlation between the presence of chromosomal translocations and the appearance of cancer cells," explains Bruschi, "so far it was not clear whether a translocation was the origin of cancer or whether, instead, it was a consequence. This is because we see patients when the cancer has already formed and in the cells already exists a particular translocation. In practice, these observations are made when it is too late to establish a relationship of cause and effect. "

An experimental study opens a way for gene therapy as a possible treatment for cases that do not respond to medicines in cases of Epilepsy. Research on Brain. Almost one third of people suffering from epilepsy don't respond to prescription drugs. To date, the only possibility for many of them is to undergo an operation to remove the area affected by the disease in the brain, but an alternative to surgery could rise by gene therapy. An experimental study of the Department of Neuroscience of Mario Negri in Milan, led by Noah, has shown that it is possible to induce the sick cells to produce a protein with anticonvulsant properties. And what this substance does is significantly reduces the recurrence of seizures. The research, conducted in collaboration with international groups led by Gunther Sperk University of Innsbruck (Austria), Asla Pitkanen University of Kuopio (Finland), and Matthew During dell'Ohio State University (USA), was just published on Brain magazine.

At the Ifom-Ieo Campus, a study began on the operation of a molecule which opens new avenues of research for less toxic treatments in chemotherapie. The study in Cell magazine. Developing new chemotherapies able to kill cancer cells without harming healthy ones: This is the goal that's still far away but we can see the light. Thanks to an international study to which has substantially contributed a team of Campus Ifom-Ieo (Foundation Institute of Molecular Oncology - European Institute of Oncology) in Milan, in fact, it was possible to identify a molecule - called Ndc80 - which could be the ideal target of new chemotherapeutic drugs, because it's active only when the cell reproduces (mitosis). The research, led by Andrea Musacchio in collaboration with Peter De Wulf, was published in the journal Cell. One of the problems with current chemotherapies is that, in addition to attacking the cancer cells, in part it also kills healthy cells. This is because the drugs (for example, taxolo) affect proteins that, although mostly engaged in the process of cell proliferation (typical of tumor masses), they are also involved in other processes with other cells that are not sick. A molecule found only in reproducing cells would be the ideal target.

In the blood of alligators and crocodiles proteins were discovered with high antibacterial and antifungal activity. Unlike men, alligators can combat fungi, viruses and bacteria without the body being previously subjected to these micro-organisms. The researchers have demonstrated the McNeese State University and Louisiana State University who collected the blood from alligators and analyzed the white blood cells, which are the cells appointed to immune defense.

A study conducted by an Italian and published on Pnas shows that healthy cells, if required to "diet", have an increased resistance to stress caused by the drugs compared with those ill. Fasting can be a weapon against the heavy effects of chemotherapy. Just as the fight against cancer concentrates its efforts on the so-called magic bullets, drugs capable of selectively target diseased cells from laboratories of the University of Southern California shows a new paradigm: protect healthy cells and then go furiously only against those sick . A team led by biologist Italian Valter Longo, which involved the United States laboratories and the hospital Gaslini of Genoa, has discovered a kind of magic screen that healthy cells (as a result of caloric restriction) have as a defense against chemotherapy. The results of the study appeared on Pnas Early Edition (here a link to the video.)

Robo4, present in the cells of the blood vessel wall, may improve or prevent the consequences of eye diseases The age-related ocular degeneration is the leading cause of blindness in people over 65 years old, and retinopathy lead to total loss of sight in most of the patients of diabetes, about 21 million in the world. In particular, the degeneration and the destabilization of the vessel wall causes many times a loss of liquid and, consequently, severe inflammation that can lead to blindness. A new protein, named Robo4, identified in cells in the wall of blood vessels, may prevent these anomalies and help reduce or even prevent various vascular diseases related to an increase. The study, conducted by Dean Li and colleagues at the University of Utah, in the United States, was published in Nature.

A study analysis conducted over the past 27 years by British researchers, suggests that some Fans can reduce the risk of developing cancer. A review of studies published over the last 27 years suggests that the anti-inflammatory non-steroidal pharmacy drugs (Fans) such as aspirin could reduce the risk of breast cancer by as much as 20 per cent! In support, some experts of Guy's Hospital in London appeared in a publication of International Journal of Clinical Practice. According to Ian Fentiman, Fans could play an important role not only in prevention, but also as a therapy for women who have developed this type of cancer, combining their use with a hormonal treatment and using them as analgesics.

A survey published on PloS Medicine considers the effects of "the happiness pill clinically nonexistent". And in Great Britain this survey resulted in an outbreak of controversy. Prozac, the antidepressant Seroxat and in general antidepressants do not produce clinically significant benefits. It had the effect of an earthquake relationship. Irving Kirsch, director of the psychology department of Hull University, which - published in the online journal PloS Medicine - assess the outcomes of total 47 studies (known and unpublished) of British and American experts on the real effects of "happiness pill", Prozac. Printed immediately on the front pages of major British newspapers, The Guardian and The Independent Times immediately attacked by the pharmaceutical companies concerned. The study argues that this type of medicines - given annually by more than 40 million people around the world -- found minimal improvements compared to the simple placebo, amounting to just two points on the Hamilton depression scale (comprising 51 points total). Findings for fluoxetine (Prozac), venlafaxine (Efexor), paroxetine (Seroxat) and similar molecules have been put on the market, but which do not reach the three points needed by the British National Institute for Clinical Excellence (Nice) to recognize their significant clinical differences .